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ImmunePhase IIBeginner

TB-500 (Immune)

Thymosin Beta-4

Also known as: TB4, Thymosin Beta-4, Tβ4

Overview

A 43-amino acid peptide ubiquitous in human cells, originally identified in the thymus. While primarily known for tissue repair (see healing-recovery category), TB-500 also plays a significant role in immune regulation through modulation of inflammatory pathways and immune cell migration.

Half-Life
~2 hours
Typical Dose
2–5 mg
Frequency
2x per week (loading), 1x per week (maintenance)
Cycle Length
4-8 weeks loading, then maintenance

Administration

SubcutaneousIntramuscular

Benefits

  • Modulates inflammatory immune responses
  • Promotes immune cell migration to sites of infection or injury
  • Reduces excessive inflammatory cytokine production
  • Supports thymic function and T-cell development
  • Anti-fibrotic effects reduce immune-mediated tissue damage
  • Promotes tissue repair following immune-mediated injury

Side Effects

  • Temporary lethargy
  • Head rush shortly after injection
  • Injection site redness
  • Mild flu-like symptoms during loading phase

Mechanism of Action

  • Sequesters G-actin to regulate immune cell cytoskeletal dynamics
  • Downregulates NF-kB-mediated pro-inflammatory signaling
  • Modulates macrophage polarization toward anti-inflammatory M2 phenotype
  • Promotes T-regulatory cell activity
  • Reduces TNF-alpha and IL-1-beta production in activated immune cells

Contraindications

  • Active cancer (promotes angiogenesis)
  • Pregnancy or breastfeeding
  • Active severe infections (theoretical immune modulation)

Storage & Reconstitution

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, refrigerate and use within 2-3 weeks.

Common peptide amounts:2 mg5 mg

Research Summary

Thymosin Beta-4 was originally isolated from the thymus and has well-documented immune-modulatory properties alongside its healing effects. Clinical trials by RegeneRx Biopharmaceuticals have explored its role in wound healing and tissue repair, with immune modulation being a key secondary mechanism. Cross-reference: see tb-500 in healing-recovery for full tissue repair profile.

Commonly Stacked With

ImmuneThymosin Alpha-1
Healing & RecoveryBPC-157
ImmuneKPV

This information is for educational purposes only. Always consult a qualified healthcare professional before using any peptide.