SS-31 (Elamipretide)

A mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane, binding to cardiolipin to stabilize electron transport chain function. SS-31 protects mitochondria from oxidative damage and restores bioenergetic capacity, addressing one of the fundamental drivers of aging.

• Binds cardiolipin in the inner mitochondrial membrane to stabilize electron transport complexes
• Reduces mitochondrial reactive oxygen species (ROS) production
• Restores ATP synthesis and mitochondrial membrane potential
• Prevents cardiolipin peroxidation to maintain cristae structure

• Severe renal impairment (use with monitoring)
• Pregnancy or breastfeeding
• Known hypersensitivity to peptide components

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, use within 24 hours or refrigerate for up to 7 days.

Developed by Stealth BioTherapeutics, elamipretide has been evaluated in multiple Phase 2 and 3 clinical trials. The TAZPOWER trial in Barth syndrome showed improvements in six-minute walk test distance. Studies in primary mitochondrial myopathy (MMPOWER) and heart failure (PROGRESS-HF) have shown mixed results, though biomarker improvements were noted. Preclinical data strongly support mitochondrial protection against age-related decline, ischemia-reperfusion injury, and neurodegenerative conditions.