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Anti-AgingPreclinicalBeginner

Pinealon

Pinealon (Glu-Asp-Arg Tripeptide)

Also known as: EDR peptide, Glu-Asp-Arg, Brain Bioregulator

Overview

A short bioregulator tripeptide (Glu-Asp-Arg) that specifically targets brain tissue, developed as part of the Khavinson peptide bioregulation program. Pinealon penetrates the blood-brain barrier and has demonstrated neuroprotective, cognitive-enhancing, and anti-aging effects on central nervous system tissues in preclinical studies.

Half-Life
~1-2 hours
Typical Dose
5–10 mg
Frequency
Once daily for 10-15 day cycles
Cycle Length
10-15 days on, 3-6 months off

Administration

OralSubcutaneousIntranasal

Benefits

  • Neuroprotective effects against oxidative stress
  • Supports cognitive function and memory in aging
  • Regulates pineal gland function and melatonin synthesis
  • Promotes neuronal survival under stress conditions
  • May improve sleep quality through circadian regulation

Side Effects

  • Mild drowsiness
  • Occasional headache
  • Generally very well tolerated

Mechanism of Action

  • Modulates gene expression in neuronal cells to promote survival pathways
  • Enhances antioxidant defense in brain tissue
  • Regulates pineal gland peptide and melatonin production
  • Supports synaptic plasticity and neurotransmitter balance

Contraindications

  • Active neurological conditions requiring medication (consult physician)
  • Concurrent use of sedatives or CNS depressants (may potentiate effects)
  • Pregnancy or breastfeeding

Storage & Reconstitution

Store capsules at room temperature (15–25°C (59–77°F)) in a cool, dry place. Injectable form: store at 2–8°C (36–46°F). Stable due to short peptide structure.

Common peptide amounts:5 mg10 mg

Research Summary

Preclinical studies have demonstrated that Pinealon protects neurons from hypoxia-induced and oxidative damage, promoting cell survival in cortical neuron cultures. Gene expression studies show modulation of apoptosis-related genes and antioxidant enzymes. In aged animal models, Pinealon courses improved learning, memory, and neuronal density. Part of the Khavinson bioregulator program that has produced over 200 publications on short peptide bioregulation. No large-scale Western clinical trials to date.

Commonly Stacked With

Anti-AgingEpithalon
Anti-AgingVilon
Anti-AgingThymalin
Anti-AgingHumanin

This information is for educational purposes only. Always consult a qualified healthcare professional before using any peptide.