PEG-MGF

A PEGylated (polyethylene glycol-conjugated) version of Mechano Growth Factor designed to overcome the extremely short half-life of native MGF. The PEG moiety shields the peptide from rapid enzymatic degradation, extending its biological activity from minutes to several hours. This allows for systemic distribution and a more practical dosing protocol while retaining MGF's satellite cell-activating properties.

• PEG moiety prevents proteolytic degradation, extending circulating half-life
• Retains MGF E-domain activity: activates satellite cells from quiescence into proliferative state
• Systemic availability allows binding to IGF-1 receptors across multiple muscle beds
• Complements endogenous post-exercise MGF expression for additive satellite cell recruitment

• Active malignancy
• Known PEG allergy or anti-PEG antibodies
• Pregnancy or breastfeeding
• History of anaphylaxis to PEGylated compounds

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, refrigerate and use within 21 days. More stable than non-PEGylated MGF.

PEG-MGF was developed to address the impractically short half-life of native MGF. Animal studies demonstrate that PEGylated MGF maintains satellite cell activation capacity while providing sustained plasma levels. Research shows significant improvements in muscle mass and strength in rodent models of muscle injury. No human clinical trials have been conducted, but the PEGylation strategy is well-established in pharmaceutical development (e.g., PEGfilgrastim, PEGinterferon).