MOTS-c

A mitochondrial-derived peptide encoded in the 12S rRNA gene that acts as a metabolic regulator. MOTS-c activates AMPK signaling, enhances glucose metabolism, and improves exercise capacity, positioning it as a novel approach to metabolic health and weight management.

• Activates AMPK pathway to promote cellular energy metabolism
• Enhances glucose uptake in skeletal muscle independent of insulin
• Regulates mitochondrial biogenesis and function
• Modulates the folate-methionine cycle affecting cellular metabolism

• Hypoglycemia or use of insulin-sensitizing drugs without monitoring
• Pregnancy or breastfeeding
• Severe metabolic disorders without medical supervision

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, refrigerate and use within 14 days.

Discovered by Dr. Pinchas Cohen's lab at USC, MOTS-c has shown in animal studies to improve metabolic homeostasis, enhance exercise capacity, and protect against age-related metabolic decline. It activates AMPK in skeletal muscle, promoting glucose metabolism. Human observational studies correlate higher endogenous MOTS-c levels with better metabolic health. Clinical trials in humans are still in early stages.