Ipamorelin

A highly selective growth hormone releasing peptide (GHRP) that stimulates GH release through the ghrelin receptor without significantly affecting cortisol, prolactin, or appetite. Considered one of the cleanest GH secretagogues available.

• Selectively activates the GHS-R1a (ghrelin) receptor on pituitary somatotrophs
• Triggers intracellular calcium signaling to promote GH vesicle exocytosis
• Does not activate pathways associated with cortisol or prolactin release

• Active malignancy
• Pregnancy or breastfeeding
• Known hypersensitivity to the compound

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, refrigerate and use within 28 days.

Ipamorelin has been studied in multiple clinical trials including post-operative ileus and growth hormone deficiency models. Research consistently demonstrates dose-dependent GH release with a favorable selectivity profile, showing no clinically significant increases in ACTH, cortisol, or prolactin at therapeutic doses. It is widely regarded as the most side-effect-friendly GHRP.