GHRP-6

A synthetic hexapeptide that potently stimulates growth hormone release via the ghrelin receptor (GHS-R1a). GHRP-6 is included in the sleep category because it significantly amplifies the nocturnal GH surge that occurs during deep sleep. Unlike Ipamorelin, GHRP-6 also strongly stimulates appetite and has broader hormonal effects (including cortisol and prolactin elevation), making it more suitable for individuals seeking both sleep enhancement and anabolic/recovery support.

• Agonism of GHS-R1a (ghrelin receptor) in the hypothalamus and pituitary
• Amplifies GHRH-mediated GH pulsatility during nocturnal slow-wave sleep
• Suppresses somatostatin to further enhance GH release amplitude
• Activates neuroprotective pathways via ghrelin receptor signaling in the CNS

• Active cancer or history of malignancy
• Diabetes or insulin resistance (monitor blood glucose closely)
• Cushing's syndrome or cortisol-related disorders
• Pregnancy or breastfeeding
• Obesity without medical supervision (appetite stimulation may be counterproductive)

Store at 2–8°C (36–46°F) for up to 3 months. Once reconstituted, refrigerate and use within 21 days. Protect from light.

GHRP-6 was one of the first synthetic GH secretagogues studied, with extensive research dating to the 1980s by Bowers et al. Clinical studies demonstrated dose-dependent GH release 5-10 times above baseline, with peak levels at 15-30 minutes post-injection. Sleep studies (Frieboes et al., 1995) showed that GH secretagogues significantly increase slow-wave sleep and nocturnal GH amplitude. Unlike Ipamorelin, GHRP-6 also elevates cortisol and prolactin, which limits its selectivity. Its strong appetite stimulation is mediated through the same ghrelin receptor pathway and can be beneficial or problematic depending on the individual's goals.