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Healing & RecoveryPhase IIBeginner

GHK-Cu

Glycyl-L-Histidyl-L-Lysine Copper Complex

Also known as: GHK, Copper Peptide, GHK Copper

Overview

A naturally occurring tripeptide with strong affinity for copper(II) ions. Found in human plasma, saliva, and urine, it declines with age. Widely used for wound healing, skin rejuvenation, and hair growth.

Half-Life
~1 hour (systemic)
Typical Dose
1–3 mg
Frequency
1x daily (injection) or 2x daily (topical)
Cycle Length
8-16 weeks

Administration

SubcutaneousTopical

Benefits

  • Accelerates wound healing and tissue remodeling
  • Stimulates collagen and elastin synthesis
  • Promotes hair follicle growth and thickness
  • Reduces fine lines, wrinkles, and photodamage
  • Antioxidant and anti-inflammatory effects
  • Attracts immune cells and promotes angiogenesis

Side Effects

  • Skin irritation with topical application (mild)
  • Injection site redness
  • Temporary skin tingling

Mechanism of Action

  • Activates genes involved in collagen synthesis and ECM remodeling
  • Stimulates decorin, glycosaminoglycan, and proteoglycan production
  • Increases superoxide dismutase (SOD) activity for antioxidant defense
  • Promotes stem cell proliferation at wound sites
  • Modulates metalloproteinase activity for scar remodeling

Contraindications

  • Wilson's disease or copper metabolism disorders
  • Pregnancy or breastfeeding
  • Known allergy to copper compounds

Storage & Reconstitution

Store at 2–8°C (36–46°F) for up to 3 months, protected from light. Once reconstituted, refrigerate and use within 2-3 weeks. Topical formulations: follow manufacturer instructions.

Common peptide amounts:5 mg10 mg50 mg

Research Summary

Over 60 years of published research since discovery in 1973 by Dr. Loren Pickart. Clinical studies demonstrate improved wound healing, increased collagen deposition, and cosmetic skin improvement. Widely used in commercial skin care with strong safety profile.

Commonly Stacked With

Healing & RecoveryBPC-157
Healing & RecoveryTB-500
Anti-AgingEpithalon

This information is for educational purposes only. Always consult a qualified healthcare professional before using any peptide.