Fragment 176-191

The C-terminal fragment of human growth hormone representing amino acids 176-191. This region is responsible for the fat-metabolizing properties of GH and has been shown to promote lipolysis without the anabolic or diabetogenic effects of full-length GH.

• Activates lipolytic pathways in adipose tissue through the C-terminal region of GH
• Inhibits de novo lipogenesis to prevent new fat storage
• Does not interact with the GH receptor in a way that triggers IGF-1 or anabolic signaling

• Active cancer
• Pregnancy or breastfeeding
• Eating disorders or severe caloric restriction

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, refrigerate and use within 14 days.

HGH Fragment 176-191 was identified through structure-function studies of growth hormone that mapped the lipolytic activity to the C-terminal region. In vitro and animal studies demonstrate it promotes fat oxidation at a rate 12.5 times greater than unmodified GH without affecting carbohydrate metabolism. It is primarily used in research settings focused on obesity and metabolic syndrome.