Epithalon

A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin produced by the pineal gland. Epithalon is one of the most studied anti-aging peptides, primarily researched for its ability to activate telomerase and thereby elongate telomeres — the protective caps on chromosomes that shorten with age.

• Activates telomerase enzyme (hTERT) to extend telomere length
• Stimulates pineal gland melatonin production for circadian rhythm regulation
• Modulates gene expression related to cellular senescence
• Enhances antioxidant defense enzymes (SOD, catalase)

• Active cancer (telomerase activation could theoretically promote tumor growth)
• Autoimmune conditions without medical supervision
• Pregnancy or breastfeeding

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, refrigerate and use within 21 days.

Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, epithalon has been studied for over 35 years. Animal studies demonstrated a 13.7% increase in lifespan in mice and significant telomere elongation in human cell cultures. A 15-year observational study in elderly patients showed improved immune function, cardiovascular health, and endocrine balance. While promising, large-scale human RCTs are still lacking.