Cortagen

A synthetic tetrapeptide bioregulator developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in Russia. Cortagen is designed to target the cerebral cortex, modulating gene expression related to neuronal function and potentially slowing age-related cognitive decline through epigenetic mechanisms.

• Penetrates cell nuclei and interacts with specific DNA sequences to regulate gene expression (epigenetic bioregulation model)
• Modulates expression of genes involved in neuronal survival and synaptic plasticity in the cerebral cortex
• Part of the cytomaxin/cytogen class of peptide bioregulators hypothesized to restore organ-specific gene expression patterns
• Antioxidant effects through upregulation of endogenous antioxidant enzyme expression

• Pregnancy or breastfeeding
• Active CNS infections
• Known hypersensitivity to short peptide bioregulators

Store at 2–8°C (36–46°F) for up to 3 months, protected from light and moisture. Once reconstituted, refrigerate and use within 10 days.

Cortagen is part of Professor Khavinson's bioregulator peptide program, which has produced over 100 published studies on short peptides that modulate gene expression in tissue-specific ways. Research on Cortagen specifically has been published in Russian biomedical journals and the Bulletin of Experimental Biology and Medicine, demonstrating effects on cortical neuron gene expression patterns and neuroprotection in aging models. The bioregulator hypothesis — that short peptides can epigenetically restore youthful gene expression — remains an active area of research, primarily in Russia and Europe.