CJC-1295 (no DAC) / Mod GRF 1-29

A short-acting GHRH analog with four amino acid substitutions that protect it from enzymatic degradation, resulting in a half-life of approximately 30 minutes. It produces acute GH pulses that more closely mimic natural physiology.

• Activates GHRH receptors on pituitary somatotrophs to trigger acute GH release
• Four amino acid substitutions (Ala2, Glu8, Ala15, Leu27) confer DPP-IV resistance
• Works synergistically with ghrelin mimetics by acting on a separate receptor pathway

• Active malignancy or history of cancer
• Pregnancy or breastfeeding
• Uncontrolled diabetes

Store at 2–8°C (36–46°F) for up to 3 months. For long-term storage, keep at -20°C (-4°F). Once reconstituted, refrigerate and use within 21 days. Avoid repeated freeze-thaw cycles.

Mod GRF 1-29 has been shown to produce significant acute GH pulses comparable to native GHRH but with improved metabolic stability. When combined with GHRPs such as ipamorelin, studies show synergistic GH release that can exceed either compound alone by 2-3 fold. It is one of the most commonly used GHRH analogs in peptide research.